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CactusCarlos
03-20-2012, 08:32 PM
Canadian researchers find a simple cure for cancer, but major pharmaceutical companies are not interested.

Researchers at the University of Alberta, in Edmonton, Canada have recently cured cancer, yet there is but little ripple in the news or on TV. It is a simple technique using a very basic drug. The method employs dichloroacetate, which is currently used to treat metabolic disorders, so there is no concern of side effects or other long term effects.

The drug doesn’t require a patent, so anyone can employ it widely and cheaply compared to the costly cancer drugs produced by major pharmaceutical companies.

http://www.moneytrendsresearch.com/scientists-cure-cancer-but-no-one-takes-notice/

Thoughts?

Rockntractor
03-20-2012, 08:54 PM
When something seems to good to be true it always is.
There have been so called miracle cures for cancer since the word was invented and people that are dying do try them, I have had many friends that died of cancer and lots of them tried non standard remedies, in the end they all ended up looking at the grass from the bottom side.

CactusCarlos
03-20-2012, 09:04 PM
When something seems to good to be true it always is.
There have been so called miracle cures for cancer since the word was invented and people that are dying do try them, I have had many friends that died of cancer and lots of them tried non standard remedies, in the end they all ended up looking at the grass from the bottom side.

Thanks for your reply! I'm cool with this being another example of something to good to be true, all I'm looking for is a person who can say why. I'm not that person, that's why I posted it.

Rockntractor
03-20-2012, 09:08 PM
Thanks for your reply! I'm cool with this being another example of something to good to be true, all I'm looking for is a person who can say why. I'm not that person, that's why I posted it.

People try anything if all else fails, if it actually works it will become well known and used.
If something like this needs a hard sell that means it doesn't work, I hope that isn't what you are doing here.

CactusCarlos
03-20-2012, 09:21 PM
People try anything if all else fails, if it actually works it will become well known and used.
If something like this needs a hard sell that means it doesn't work, I hope that isn't what you are doing here.

It is not - I posted the same thread at another board and at FreeRepublic. You probably don't know me (I'm not that memorable anyway) but I'm known at another board that has members that are here.

Gentleman Pirate
03-20-2012, 09:22 PM
http://www.cancer.org/AboutUs/DrLensBlog/post/2010/05/14/More-On-Dichloroacetate-(DCA)-In-Cancer-Treatment.aspx


Doesn't look like there have been many clinical trials to support the claims, but this doctor is intrigued about the possibilities.

Elspeth
03-24-2012, 10:22 PM
Here's the researcher's web page:

http://www.dca.med.ualberta.ca/Home/index.cfm

ome
The Official University of Alberta DCA Website
The University of Alberta Discovery

DCA is an odourless, colourless, inexpensive, relatively non-toxic, small molecule. And researchers at the University of Alberta believe it may soon be used as an effective treatment for many forms of cancer.

Dr. Evangelos Michelakis, a professor at the U of A Department of Medicine, has shown that dichloroacetate (DCA) causes regression in several cancers, including lung, breast, and brain tumors.

Michelakis and his colleagues, including post-doctoral fellow Dr. Sebastien Bonnet, have published the results of their research in the journal Cancer Cell.

Scientists and doctors have used DCA for decades to treat children with inborn errors of metabolism due to mitochondrial diseases. Mitochondria, the energy producing units in cells, have been connected with cancer since the 1930s, when researchers first noticed that these organelles dysfunction when cancer is present.

Until recently, researchers believed that cancer-affected mitochondria are permanently damaged and that this damage is the result, not the cause, of the cancer. But Michelakis, a cardiologist, questioned this belief and began testing DCA, which activates a critical mitochondrial enzyme, as a way to "revive" cancer-affected mitochondria.

The results astounded him.

Michelakis and his colleagues found that DCA normalized the mitochondrial function in many cancers, showing that their function was actively suppressed by the cancer but was not permanently damaged by it.

More importantly, they found that the normalization of mitochondrial function resulted in a significant decrease in tumor growth both in test tubes and in animal models. Also, they noted that DCA, unlike most currently used chemotherapies, did not have any effects on normal, non-cancerous tissues.

"I think DCA can be selective for cancer because it attacks a fundamental process in cancer development that is unique to cancer cells," Michelakis said. "One of the really exciting things about this compound is that it might be able to treat many different forms of cancer".

Another encouraging thing about DCA is that, being so small, it is easily absorbed in the body, and, after oral intake, it can reach areas in the body that other drugs cannot, making it possible to treat brain cancers, for example.

Also, because DCA has been used in both healthy people and sick patients with mitochondrial diseases, researchers already know that it is a relatively non-toxic molecule that can be immediately tested patients with cancer.

"The results are intriguing because they point to the critical role that mitochondria play: they impart a unique trait to cancer cells that can be exploited for cancer therapy"
Dario Alteri
Director University of Massachusetts Cancer Center

Investing in Research

The DCA compound is not patented and not owned by any pharmaceutical company, and, therefore, would likely be an inexpensive drug to administer, says Michelakis, the Canada Research Chair in Pulmonary Hypertension and Director of the Pulmonary Hypertension Program with Capital Health, one of Canada's largest health authorities.

However, as DCA is not patented, Michelakis is concerned that it may be difficult to find funding from private investors to test DCA in clinical trials. He is grateful for the support he has already received from publicly funded agencies, such as the Canadian Institutes for Health Research (CIHR), and he is hopeful such support will continue and allow him to conduct clinical trials of DCA on cancer patients.

Michelakis' research is currently funded by the CIHR, the Canada Foundation for Innovation, the Canada Research Chairs program, and the Alberta Heritage Foundation for Medical Research.

"This preliminary research is encouraging and offers hope to thousands of Canadians and all others around the world who are afflicted by cancer, as it accelerates our understanding of and action around targeted cancer treatments," said Dr. Philip Branton, Scientific Director of the CIHR Institute of Cancer.

DCA and Cancer Patients

The University of Alberta's DCA Research Team is set to launch clinical trials on humans in the spring of 2007 pending government approval. Knowing that thousands of cancer patients die weekly while waiting for a cure, Dr. Michelakis and his team are working at accelerated speed, condensing research that usually takes years into months. Fundraisers at the University of Alberta are determined to raise the money to allow this next phase of research to begin. Once Health Canada grants formal approval, the University of Alberta's Research Team will begin testing DCA on patients living with cancer. Results with regards to the safety and efficacy of treatment should be known late this year.

Elspeth
03-24-2012, 10:29 PM
And here is a warning from 2007

http://www.nationalreviewofmedicine.com/issue/2007/04_15/4_patients_practice2_7.html

Quacks pervert U of A doc's discovery

Desperate cancer patients clamour for untested DCA "cure"

By Gillian Woodford

A physician's DCA experiment

One string of posts on TheDCAsite.com by a patient calling himself "Squareb" has aroused special interest. Squareb describes himself as a physician in his forties with metastatic sarcoma; he says he's taking DCA with his oncologist's blessing. Here's an excerpt:

February 27, 2007 — Day 3
I have been taking [DCA] for three days. I notice no side effects, except maybe a little lethargy, but that may be from the thiamine supplement. I am taking the sodium DCA at 1.25 mg/kg twice daily. I plan to increase it to 2.5 mg twice daily. I dissolve it in 8 ounces of water. It has a slightly salty taste that reminds me of the potassium salts they use as salt substitutes.

March 13, 2007 — Day 15
I don't think I have any significant side effects.

March 19, 2007 — Day 24
I do not think DCA does nothing. On the other hand it is not the magic bullet everyone had hoped for. It will probably be an useful adjunct to use with other chemotherapies or radiation.

Two days later, Squareb stopped taking DCA.

March 26, 2007 — Day 31
My experience with DCA's side effects really started about day 25 when I had increasing malaise and the start of tremors in my hands. Numbness in my hands started on day 27, the day after I stopped my dose of 25mg/kg twice daily. This is neuropathy from DCA. The general feeling of malaise culminated on day 29. On that day I was feeling more lousy than usual. Suddenly I felt as if my whole body was withdrawing inwards even though I was sitting motionless on the couch. I thought I was telling my last words to my wife. I have a glucometer... I drank some juice and ate some salad. The feeling started resolving within 15 minutes. I am convinced this was hypoglycemia.

March 29, 2007 — following CT scans
The tumour growth resumed at about the previous pace during the DCA treatment.... DCA may work on certain tumours or combination with other drugs, but it obviously did not work on my metastatic sarcoma tumours.

Source: www.TheDCAsite.com

Dr Evangelos Michelakis is living every researcher's worst nightmare.

The therapy he painstakingly studied, verified and re-verified, has been hijacked and risks harming the very people it was meant to heal.

Just two short months ago the University of Alberta cardiologist was on top of the world following the publication of his paper on an obscure molecule called dichloroacetate (DCA) in the journal Cancer Cell. His discovery that DCA could shrink cancer cells was instantly hailed as a long-awaited cure for the most feared of all diseases.

But disturbing reports soon overshadowed his enthusiasm. He heard that vulnerable terminal cancer patients took the proclamations a little too closely to heart and have been buying DCA over the internet and self-medicating, even though DCA hasn't yet been tested in humans.

TRY SOME, BUY SOME
Dr Michelakis' study found that DCA can shrink cells by 'reviving' cancer-affected mitochondria. This flew in the face of the long-held belief that these mitochondria were irrevocably damaged and that this damage is the result, not the cause, of the cancer.

This was an exciting discovery in itself, but Dr Michelakis warns it's been taken out of context and is being used to exploit desperate patients.

Media reports that DCA won't get developed because drug companies can't patent the molecules (this fact has been used in DCA fundraising by U of A) caused outrage from patients. There were also claims that DCA can be cheaply and easily made from components purchased from chemical suppliers (partly true) and that it has no side-effects (false). DCA has long been used to treat rare metabolic disorders in children but is known to cause peripheral neuropathy in adults.

Despite the dangers, Californian biologist-cum-huckster Jim Tassano has started selling DCA on a website called BuyDCA.com. Although the site says it's only for veterinary use, a sister site, TheDCAsite.com, openly promotes its use in humans. "He's a pest exterminator with a biology degree who's hired a chemist and is profiting from desperate people," fumed Dr Michelakis in the Edmonton Sun. "He is bypassing every regulatory principle that exists to ensure pharmaceuticals are safe and selling hope for money. It's horribly unethical."

Mr Tassano, who sells DCA for 90 cents a gram, denies he's in it for the money, saying he got involved because he wanted to save his terminally ill ballroom dance instructor's life.

TheDCAsite.com features a message board where patients recount their experiences taking DCA (sadly, most have been negative — see "A physician's DCA experiment" below). "That's the worst nightmare in medicine, to start making judgments on whether a drug is good or bad based on what any patient will post on a blog," said Dr Michelakis in the Edmonton Journal. "This is the death of medicine and organized research as we know it."

VOICES OF REASON
When the Canadian Cancer Society started being flooded with calls from patients about DCA, mostly urging them to fund research, it felt compelled to issue a warning. "It took on a life of its own," says nurse Heather Logan, the Canadian Cancer Society's director of cancer control policy, speaking from her office in Toronto. "We heard patients in end stage were mixing DCA at home and we grew increasingly concerned."

The Society is investigating the therapy's validity to see if it's worth proceeding to clinical trial. Dr Michelakis is hoping to start DCA trials in humans as early as this spring, pending Health Canada approval. In the meantime he strongly urges patients to wait for the clinical trial results.

Ms Logan is still very much intrigued by the original study. "The authors didn't overstate the findings," she says. "I hope it's a breakthrough."

Zeus
03-24-2012, 10:37 PM
Hell radiation therapy & Chemotherapy can cure cancer too. The only problem is will it kill the cancer before it kills the patient.

NJCardFan
03-24-2012, 10:44 PM
When something seems to good to be true it always is.
There have been so called miracle cures for cancer since the word was invented and people that are dying do try them, I have had many friends that died of cancer and lots of them tried non standard remedies, in the end they all ended up looking at the grass from the bottom side.
I know of someone who was cured of cancer, leukemia at least. And it was an experimental treatment. http://www.dailymail.co.uk/news/article-2037076/Bill-Ludwigs-immune-trained-kill-cancer-reconstructed-form-HIV.html Now, in case you're thinking that this is some far out story, this is a story about my father-in-law. The man in the picture in the article is that same man. So it is possible. Not saying this is all that but just saying this isn't impossible.

noonwitch
03-27-2012, 03:14 PM
When something seems to good to be true it always is.
There have been so called miracle cures for cancer since the word was invented and people that are dying do try them, I have had many friends that died of cancer and lots of them tried non standard remedies, in the end they all ended up looking at the grass from the bottom side.


I had a second or third cousin who was a cancer researcher (Grandpa's niece by his half-sister). She and her husband truly believed that megadoses of vitamin C could cure cancer. I remember when I was 15 or so, and they came to visit us (after being kicked out of Tito's Yugoslavia) and were telling us of their research. They also had invented a machine that could detect cancer from one blood test, and pinpoint it's location with a second test. This was in the mid to late 70s-I suspect that the machine was not as accurate as they claimed.

I'm sure that at some point in time, a cancer cure will be developed, but it won't be as easy as this appears to be and probably some other disease will come along to keep the population in check, if one believes in the Malthusian Trap.