Ned Flanders is a truly good person, who struggles to be true to his faith. Sometimes he looks like a fool, but he never is mean or petty. Part of the reason Homer hates him is because Homer feels inadequate by comparison.
I doubt this show will do very well. ABC is struggling, and shows over the past decade or so that took a serious look at religion managed to offend people, I'm pretty sure a show with a title like this will do so even more thoroughly.
I went to Catholic school. The image of Jesus is everywhere, as is the image of Mary. But while Mary is spoken of frequently, Jesus is rarely mentioned by name in the course of a normal day outside of religion class. Even religion class only talks about Jesus when he's present in the portion of the Bible or Biblical account being taught.
My father's family were Methodists of the in town variety, and while they may have made a break from the Episcopalian church centuries before, there really wasn't a great deal of difference in delivery. My mom's family were Episcopalians. Neither of these denominations use the word "Jesus" a lot in normal conversation. Certainly not like one encounters with more evangelical sects who are raised to have a more familiar and conversational relationship with Jesus.
Episcopalians, Methodists, and Catholics usually refer to "God" and God's wishes/punishments/rewards while Baptists and nondenominationals tend to refer to "Jesus". You aren't likely to hear an Anglican say, 'You need to get right with Jesus." anymore than you are likely to hear a contemporary hymn at an Anglican or Catholic service.
By the same token, the sermons at Holy Communion oriented churches tend to be academic lectures on personal excellence, emotional health, or ethics explained through the application of scripture. Occasionally a social issue will make the grade, but you'll rarely if ever see the kind of social issue or political ranting that you do on any given broadcast of some of these megachurches.
So that's why I asked. If you belong to a denomination where someone would actually ask you to ask yourself 'What would Jesus do?" then your experience is probably different from most television writers and your expectations will be different.