Both of my maternal grandmother's sisters - dead in their 60s and 70s, (both from cancer, IIRC)
Dad's grandfather -dead at 57 (also from cancer, but I'm of the impression he was left a wreck of a man by his wife -whom not to much of my family is fond of- and because they were both a part of a denomination that had forbidden divorce, he had no way out of that marriage.)
Great grandfather on mother's side -died a year before I was born, (damn shame too -I'm told he was one of the most out-going guys in my family) He had blacklung, though, and I think that's what killed him.
So yeah, I suppose so.
There's also David, smokes and is still upbeat to this day (I think in his late 70s, currently.)