On June 5, 2004, Karel opened his weekend KGO program with a clip of The Wizard of Oz song, "Ding-Dong the Witch is Dead!" as a "tribute" to former President Ronald Reagan, who had died earlier that day. Bouley ranted about Reagan during the first two hours of his show because of what he saw as the inaction of Reagan and his administration in the face of the then-new AIDS crisis. Bouley was severely reprimanded by KGO management for his remarks about Reagan. He later apologized on-the-air for choosing to air his comments the same day as the former president's death and later included an open letter of apology to Nancy Reagan in his book You Can't Say That.
 Tony Snow
On March 27, 2007, Karel wrote the following for the online The Huffington Post, regarding reports that White House spokesman Tony Snow had developed cancer in his colon:
"I hear about Tony Snow and say to myself, well, stand up every day, lie to the American people at the behest of your dictator-esque boss and well, how could a cancer not grow in you. Fox News spun the truth into a billion knots and spurred the controversy.
Consequently, the draft was replaced and Karel's inflammatory statements removed. The original post, however, got wide airplay in print, on television, and the Internet, compelling Huffington Post editor Roy Sekoff to speak out about the issue on The O'Reilly Factor shortly after the row.