The Rt Rev Patrick O'Donoghue, the Bishop of Lancaster, has claimed that graduates are spreading scepticism and sowing dissent. Instead of following the Church's teaching they are "hedonistic", "selfish" and "egocentric", he said.
In particular, the bishop complained that influential Catholics in politics and the media were undermining the Church.
While not naming names, he suggested that such people had been compromised by their education, which he said had a "dark side, due to original sin".
Prominent Catholics in public life include Mark Thompson, the BBC's director general, and Tony Blair, the former Prime Minister.
Bishop O'Donoghue, who has recently published a report on how to renew Catholicism in Britain, argued that mass education has led to "sickness in the Church and wider society".
"What we have witnessed in Western societies since the end of the Second World War is the development of mass education on a scale unprecedented in human history - resulting in economic growth, scientific and technological advances, and the cultural and social enrichment of billions of people's lives," he said.
"However, every human endeavor has a dark side, due to original sin and concupiscence. In the case of education, we can see its distortion through the widespread dissemination of radical skepticism, positivism, utilitarianism and relativism.