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  1. #1 Father-In-Law In Time Magazine 
    Power CUer NJCardFan's Avatar
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    I hate this leftist rag but this time(no pun intended) I have to buy it: http://time.com/4895010/cancers-newe.../?xid=homepage

    The date July 31 has always been a milestone for Bill Ludwig, a retired corrections officer in New Jersey. It's the day that he joined the Marines as an 18-year-old, and the day, 30 years later, that he married his wife Darla.
    It was also the day he went to the hospital to become the first person ever to receive the combination gene and CAR T cell therapy, in 2010. For Ludwig, the experimental therapy was his only remaining option. Like many people with leukemia, Ludwig had been living on borrowed time for a decade, counting the days between the chemotherapy treatments that would hold the cancer in his blood cells at bay for a time. Inevitably, like weeds in an untended garden, the leukemia cells would grow and take over his blood system again.
    But the periods of reprieve were getting dangerously short. "I was running out of treatments," says Ludwig. So when his doctor mentioned the trial conducted by June and Porter at the University of Pennsylvania, he didn't hesitate. "I never thought that the clinical trial was going to cure me," he says. "I just wanted to live and to continue to fight. If there was something that would put me into the next month, still breathing, then that's what I was looking for."
    When Ludwig signed the consent form for the treatment, he wasn't even told what to expect in terms of side effects or adverse reactions. The scientists had no way of predicting what would happen. "They explained that I was the first and that they obviously had no case law, so to speak," he says. So when he was hit with a severe fever, had difficulty breathing, showed signs of kidney failure and was admitted to the intensive care unit, he assumed that the treatment wasn't working.
    His condition deteriorated so quickly and so intensely that doctors told him to call his family to his bedside, just four days after he received the modified cells. "I told my family I loved them and that I knew why they were there," he says. "I had already gone and had a cemetery plot, and already paid for my funeral."
    Rather than signaling the end, Ludwig's severe illness turned out to be evidence that the immune cells he received were furiously at work, eliminating and sweeping away the huge burden of cancer cells choking up his bloodstream. But his doctors did not realize it at the time.
    It wasn't until the second patient, Doug Olson, who received his CAR T cells about six weeks after Ludwig, that Porter had a eureka moment. When he received the call that Olson was also running a high fever, having trouble breathing and showing abnormal lab results, Porter realized that these were signs that the treatment was working. "It happens when you kill huge amounts of cancer cells all at the same time," Porter says. What threw him off initially is that it's rare for anything to wipe out that much cancer in people with Ludwig's and Olson's disease. June and Porter have since calculated that the T cells obliterated anywhere from 2.5 lb. to 7 lb. of cancer in Ludwig's and Olson's bodies. "I couldn't fathom that this is why they both were so sick," says Porter. "But I realized this is the cells: they were working, and working rapidly. It was not something we see with chemotherapy or anything else we have to treat this cancer."
    From the article, this is him today:

    Deplorably Proud To Be An American
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  2. #2  
    Moderator RobJohnson's Avatar
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    He looks great!
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  3. #3  
    Power CUer NJCardFan's Avatar
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    Quote Originally Posted by RobJohnson View Post
    He looks great!
    He does. He and my MIL are currently at Yellowstone and Mount Rushmore. Getting their moneys worth out of that motorhome this year. They're coming with us to Disney in October.
    Deplorably Proud To Be An American
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    eeeevil Sith Admin SarasotaRepub's Avatar
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    Very cool!!
    May the FORCE be with you!
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  5. #5  
    Ancient Fire Breather Retread's Avatar
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    Congratulations all around on research well done and the benefits received!!
    It's not how old you are, it's how you got here.
    It's been a long road and not all of it was paved.
    A man is but a product of his thoughts. What he thinks, he becomes. Gandhi
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  6. #6  
    Festivus Moderator ralph wiggum's Avatar
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    Excellent! Haven't read it yet, it gets deposited on my coffee table. The covers have been ridiculous lately, but I'll definitely check this out.
    Voted hottest "chick" at CU - My hotness transcends gender
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